My wifes grandmother is convinced she got
Guillain-Barré Syndrome
as a result of a flu shot in the early 90's she was lucky to survive it and was in the hospital for 6 months and never recovered from it, the stats say 1 in one million this happens too.
She has been in a wheel chair every since, she has limited hand use but can stand to wash dishes etc...
she is now 85 years old, her mind is sharp but her physical condition is sad...
This was a woman who never sat still (like my wife) and is always doing something...