I've let everyone pound on Familyguy a bit, before jumping in to defend him because I concur, there are good reasons for making a night delivery.
He is absolutely 100% correct about his assesment on the inherent dangers of driving a TT at night around Western PA and Eastern Ohio. The terrain in their region is similar to WV. PA puts out their own truck route map for state routes allowing trucks. The catch is most of those state routes were cut into mountains before TT were concieved and though they are legal truck routes OH and PA both, they are NOT PHYSICALLY WIDE ENOUGH FOR A TRACTOR TRAILER IN CURVES. Having yanked steel up, down and around those roads at night, I can honestly say you better be on your game. If you aren't 100%, you will probably mis-sync a curve and scuff a wall or drive over the four wheeler coming at you.
Its very easy to misjudge and burn the shoulder also. Nothing like coming off a mountain, around a curve and finding a car backing into the road in front of you. I almost crushed a deputy sheriff one day because he came around a ninety degree curve over the Yellow line. Hoped his bladder wasn't full. IMO, unless you are familiar w/the routes you're driving on, safety is definitely an issue.