I do it weekly, and feel great. 600 miles a day (daylight driving!), then get out and walk for an hour most nights to relax. But the truck I drive runs 67 mph, and I pull 22,000 lbs loads. Now I mostly pull 53s, but still pups on occasions. I do admit tho- 600 miles of nights would suck/wear you out. Especially where I drive. I want to be able to see where there's road and not just snow.
This last two years I run Indy to Bristol Indiana to El Paso Texas, then back to Indy. 3240 miles. The six years prior I ran Indy to Denver to Salt Lake City, then back to Indy. 3220 miles, and I helped unload those (caskets). Great exercise. Wyoming wind, or Colorado snow. Worst part of that run was if I had to chain up. Electronic logs for the past 10 years, normally have 6 hrs left in my 70, and spend 49-50 hrs off at home. And I get an extra $40 per night for being away from home/being in the sleeper. Wish I was home more, but people are Dying for me to work!!!!